Frederick was trained in piety and sacred learning among the clergy of the Church of Utrecht. Being ordained priest, he was charged by Bishop Ricfried with the care of instructing converts, and about 825 he was chosen to succeed him as bishop of Utrecht. The new bishop at once began to establish order everywhere, and sent St. Odulf and other zealous and virtuous labourers into the northern parts to dispel the paganism which still subsisted there.
According to tradition St. Frederick became involved in the difficulties between the sons of the emperor, Louis the Debonair, and their father and step-mother. During these disturbances the party of the young princes charged the Empress Judith with numerous immoralities. Whatever may have been the truth of these stories, St. Frederick is said to have admonished her of them, with charity but with the effect of drawing upon himself the fury and resentment of the empress. He also got himself disliked elsewhere. The inhabitants of Walcheren were barbarous and most averse from the Gospel. On which account, St. Frederick, when he sent priests in the northern part of his diocese, took this most dangerous and difficult part chiefly to himself; and nothing gave him more trouble than marriages contracted within the forbidden decrees and the separation of the parties.
On July 18, 838, after St. Frederick had celebrated Mass and was about to make his thanksgiving, he was stabbed by two assassins. He died in a few minutes, reciting that verse of Psalm 144, "I will praise the Lord in the land of the living".
St. Frederick composed a prayer to the Blessed Trinity which for many ages was used in the Netherlands. The reputation of his sanctity appears from a poem of Rabanus Maurus, his contemporary, in praise of his virtues.